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currently has no established place in the treatment of insomnia.

(C) Other Alternative Remedies
Valerian and kava-kava are used to treat insomnia even though evidence for efficacy, purity and safety is lacking.

¥±. Antidepressant Drugs
Sedating antidepressants have been used to induce sleep in doses lower than those generally used for depression in an attempt to avoid the benzodiazepines' liabilities of dependence, rebound insomnia, and withdrawal effects. Low-dose tricyclic antidepressants(TCAs), such as amitriptyline or doxepin, were once the most commonly used antidepressants for insomnia.

Trazodone in doses of 50-200mg at bedtime has more recently become the preferred antidepressant for insomnia..

¥². Benzodiazepines(BDPs)
(A) Benzodiazepines with longer elimination half-lives.
Flurazepam
usual dose : 7.5-15mg, onset : 30-60minutes,
duration : 10 hours
Such a long elimination half-life minimizes the risk of rebound insomnia, but makes morning hangover, or daytime sedation, more likely.
Quazepam is very similar to fluazepam.

(B)Benzodiazepines with shorter elimination half-lives.
Temazepam- elimination half-life: 8-20hours
Triazolam- elimination half-life: 2-6hours, usual dose:
0.125-0.25mg, onset: 30minutes.
Estazolam is most similar to temazepam.
The benefits of a shorter half-life drug on next-day performance were countered by the increased risk of rebound insomnia and new memory impairment (anterograde amnesia) that was not commonly seen with the longer half-life drugs.

¥³. Novel Nonbenzodiazepine Hypnotic Drugs.
Hypnotic with a specific effect on the omega-1 receptor. (The benzodiazepine receptors are known as omega-1, omega-2 and omega-3 receptors).

(A) Zolpidem
Due to its specificity, zolpidem lacks anticonvulsant, muscle relaxant, and anxiolytic effects, and has been shown to have less effect on sleep architecture and next-day performance compared to benzodiazepines. Its hypnotic efficacy is the same as that o< ÀúÀÛ±ÇÀÚ © ¾à±¹½Å¹® ¹«´ÜÀüÀç ¹× Àç¹èÆ÷±ÝÁö >
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